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Article

A role for transcriptional repression of p21 <sup>CIP1</sup> by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest

1 Aug 2000

Abstract excerpt

c-Myc plays a vital role in cell-cycle progression. Deregulated expression of c-Myc can overcome cell-cycle arrest in order to promote cellular proliferation. Transforming growth factor beta (TGFbeta) treatment of immortalized human keratinocyte cells inhibits cell-cycle progression and is characterized by down-regulation of c-Myc followed by up-regulation of p21(CIP1). A direct role of c-Myc in this pathway was...

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Identifiers

PMID: 10920185
DOI: 10.1073/pnas.150006697

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Source receipt: pubmed, retrieved 7 Sept 2026.

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A role for transcriptional repression of p21 <sup>CIP1</sup> by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrestPMID 10920185Read ↗

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p21 <sup>CIP1</sup> attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivoSemantic proximity Read ↗

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Suppression of p21 by c-Myc through members of miR-17 family at the post-transcriptional levelSemantic proximity Read ↗

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