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Article

Overexpression of <i>MYC</i> causes <i>p53</i> -dependent G <sub>2</sub> arrest of normal fibroblasts

29 Aug 2000

Abstract excerpt

Overexpression of the proto-oncogene MYC has been implicated in the genesis of diverse human cancers. One explanation for the role of MYC in tumorigenesis has been that this gene might drive cells inappropriately through the division cycle, leading to the relentless proliferation characteristic of the neoplastic phenotype. Herein, we report that the overexpression of MYC alone cannot sustain the division cycle of...

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PMID: 10962037
DOI: 10.1073/pnas.190327097

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Overexpression of <i>MYC</i> causes <i>p53</i> -dependent G <sub>2</sub> arrest of normal fibroblastsPMID 10962037Read ↗

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