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Article

Mediation of c-Myc-Induced Apoptosis by p53

30 Sept 1994

Abstract excerpt

The cellular proto-oncogene c-myc is involved in cell proliferation and transformation but is also implicated in the induction of programmed cell death (apoptosis). The same characteristics have been described for the tumor suppressor gene p53, the most commonly mutated gene in human cancer. In quiescent mouse fibroblasts expressing wild-type p53 protein, activation of c-Myc was found to induce apoptosis and cell...

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Identifiers

PMID: 8091232
DOI: 10.1126/science.8091232

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mediation of c-Myc-Induced Apoptosis by p53PMID 8091232Read ↗

Evidence that c-myc mediated apoptosis does not require wild-type p53 during lymphomagenesis.Semantic proximity Read ↗

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.Semantic proximity Read ↗

p53-Dependent Transcriptional Repression of c-myc Is Required for G1 Cell Cycle ArrestSemantic proximity Read ↗

Egr1 mediates p53-independent c-Myc–induced apoptosis via a noncanonical ARF-dependent transcriptional mechanismSemantic proximity Read ↗

Role of Three Cancer ≪Master Genes≫ P53, Bcl2 and C-Myc on the Apoptotic ProcessSemantic proximity Read ↗

Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma line.Semantic proximity Read ↗

Cell death regulation during multistep lymphomagenesis.Semantic proximity Read ↗

c-Myc augments gamma irradiation-induced apoptosis by suppressing Bcl-XL.Semantic proximity Read ↗

Cooperation between p53-dependent and p53-independent apoptotic pathways in myeloid cells.Semantic proximity Read ↗

P53 is necessary for the apoptotic response mediated by a transient increase of Ras activity.Semantic proximity Read ↗

The heparin-binding domain and V region of fibronectin regulate apoptosis by suppression of p53 and c-myc in human primary cells.Semantic proximity Read ↗

Characterization of the molecular mechanisms for p53-mediated differentiation.Semantic proximity Read ↗

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