Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

doi:10.1101/gad.8.23.2817

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Article

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

Genes & development - 1 Dec 1994

Wagner A J, Kokontis J M, Hay N

Abstract excerpt

Deregulated expression of the c-myc proto-oncogene can lead to apoptosis under certain physiological conditions. By introducing a conditionally active Myc allele into primary embryo fibroblasts null for p53, and into fibroblasts without endogenous p53 expression but ectopically expressing a tempe...

Topics

Alleles
Animals
Apoptosis
Cell Cycle
Cell Division
Cell Line
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinases
Cyclins
Cycloheximide
Embryo, Mammalian
Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

G1 Phase

Gene Expression

Genes, myc

Genes, p53

Isoleucine

Mice

Source

Open in PubMed

Identifiers

PMID: 7995520
DOI: 10.1101/gad.8.23.2817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7995520-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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