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Article

p53 is a NF-Y- and p21-independent, Sp1-dependent repressor of cyclin B1 transcription.

FEBS letters - 14 Feb 2005

Innocente Steven A, Lee Jonathan M

Abstract excerpt

The p53 tumour suppressor protein is a DNA-binding transcription factor activated in response to DNA damage. Inactivation of the p53 gene occurs in 40-60% of human tumours and a substantial body of work indicates that loss of p53 activity is a critical step in oncogenesis. p53 helps to protect against neoplasia by inducing death in cells that have sustained irreparable DNA damage or by blocking cell cycle...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15710382
DOI: 10.1016/j.febslet.2004.12.073

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p53 is a NF-Y- and p21-independent, Sp1-dependent repressor of cyclin B1 transcription.PMID 15710382Read ↗

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