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Transcriptional Regulation of Mitotic Checkpoint Gene MAD1 by p53

1 Sept 2003

Abstract excerpt

p53 regulates a number of genes through transcriptional activation and repression. p53-dependent mitotic checkpoint has been described, but the underlying mechanism is still obscure. Here we examined the effect of p53 on the expression of a human mitotic checkpoint protein, Mitosis Arrest Deficiency 1 (MAD1), in cultured human cells. The expression of MAD1 was reduced when the cells were overexpressing...

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PMID: 12876282
DOI: 10.1074/jbc.m307185200

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