Article
Aprt/Opn double knockout mice: osteopontin is a modifier of kidney stone disease severity.
Kidney international - 1 Sept 2005
Vernon Hilary J, Osborne Christine, Tzortzaki Eleni G, Yang Min, Chen Jianmen, Rittling Susan R, Denhardt David T, Buyske Steven, Bledsoe Sharon B, Evan Andrew P, Fairbanks Lynette, Simmonds H Anne, Tischfield Jay A, Sahota Amrik
Abstract excerpt
BACKGROUND: Osteopontin (OPN) is reported to have two distinct functions in kidney disease: Promotion of inflammation at sites of tissue injury, and inhibition of calcium oxalate monohydrate stone formation. However, many of the studies supporting these functions were carried out in animal models of acute renal injury or in cultured cells; thus, the role of OPN in chronic renal disease is not well defined. We...
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