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Article

Sequential analysis of kidney stone formation in the Aprt knockout mouse.

Kidney international - 1 Sept 2001

Evan A P, Bledsoe S B, Connors B A, Deng L, Liang L, Shao C, Fineberg N S, Grynpas M D, Stambrook P J, Youzhi S, Sahota A, Tischfield J A

Abstract excerpt

BACKGROUND: We have previously shown that, as in human adenine phosphoribosyltransferase (APRT) deficiency, Aprt knockout mice form 2,8-dihydroxyadenine (DHA) renal stones. The disease develops earlier and is more severe in male than in female mice. To examine the biological bases for these differences, the area occupied by DHA crystals was quantified in kidney sections from male and female mice (strain 129) aged...

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Source

Identifiers

PMID: 11532086
DOI: 10.1046/j.1523-1755.2001.060003910.x

Genes

APRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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