Article
The role of osteopontin in the development of albuminuria.
Journal of the American Society of Nephrology : JASN - 1 May 2008
Lorenzen Johan, Shah Rajshree, Biser Alisha, Staicu Serban A, Niranjan Thiruvur, Garcia Ana Maria, Gruenwald Antje, Thomas David B, Shatat Ibrahim F, Supe Katarine, Woroniecki Robert P, Susztak Katalin
Abstract excerpt
Several gene array studies have suggested that osteopontin (Opn) expression strongly correlates with albuminuria and glomerular disease. Urinary Opn concentration and kidney Opn immunoreactivity were found to be increased in patients with steroid-sensitive nephrotic syndrome. In addition, renal Opn mRNA was increased in the Ins2(Akita) mouse model of type 1 diabetic nephropathy, in the LPS-induced albuminuria...
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