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Article

Obstructive uropathy in the mouse: role of osteopontin in interstitial fibrosis and apoptosis.

Kidney international - 1 Aug 1999

Ophascharoensuk V, Giachelli C M, Gordon K, Hughes J, Pichler R, Brown P, Liaw L, Schmidt R, Shankland S J, Alpers C E, Couser W G, Johnson R J

Abstract excerpt

BACKGROUND: Osteopontin is a macrophage adhesive protein that is expressed by renal tubules in tubulointerstitial disease. METHODS: To investigate the function of OPN, we induced tubulointerstitial disease in OPN null mutant (OPN-/-) and wild-type (OPN+/+) mice by unilateral ureteral ligation. Tissue was analyzed for macrophages (ED-1), types I and IV collagen deposition, TGF-beta expression, and for tubular and...

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Source

Identifiers

PMID: 10432396
DOI: 10.1046/j.1523-1755.1999.00580.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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