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Article

Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2(-/-) mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2006

Harmey Dympna, Johnson Kristen A, Zelken Jonathan, Camacho Nancy P, Hoylaerts Marc F, Noda Masaki, Terkeltaub Robert, Millán José Luis

Abstract excerpt

UNLABELLED: Increased levels of ePP(i) in mice deficient in TNALP (i.e., Akp2(-/-)) lead to elevated OPN concentrations. We examined the skeletal phenotype of mice lacking both OPN and TNALP and concluded that the increased OPN levels contribute to the hypophosphatasia phenotype characteristic of...

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Source

Identifiers

PMID: 16939396
DOI: 10.1359/jbmr.060619

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16939396-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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