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Article

Osteopontin deficiency dampens the pro-atherogenic effect of uraemia.

Cardiovascular research - 1 Jun 2013

Pedersen Tanja X, Madsen Marie, Junker Nanna, Christoffersen Christina, Vikeså Jonas, Bro Susanne, Hultgårdh-Nilsson Anna, Nielsen Lars Bo

Abstract excerpt

AIMS: Uraemia is a strong risk factor for cardiovascular disease. Osteopontin (OPN) is highly expressed in aortas of uraemic apolipoprotein E knockout (E KO) mice. OPN affects key atherogenic processes, i.e. inflammation and phenotypic modulation of smooth muscle cells (SMCs). We explored the role of OPN on vascular pathology in uraemic mice. METHODS AND RESULTS: Uraemia was induced by 5/6 nephrectomy in E KO and...

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Source

Identifiers

PMID: 23455547
DOI: 10.1093/cvr/cvt049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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