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Article

Gender- and age-dependent changes in kidney androgen protein mRNA expression in a knockout mouse model for nephrolithiasis.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Dec 2002

Tzortzaki Eleni G, Glass Dayna, Yang Min, Evan Andrew P, Bledsoe Sharon B, Stambrook Peter J, Sahota Amrik, Tischfield Jay A

Abstract excerpt

Kidney androgen-regulated protein (Kap) is the most abundant protein in the mouse kidney, but its function is unknown. We previously observed a significant decrease in Kap mRNA expression in whole kidney tissue from male mice with adenine phosphoribosyltransferase (APRT) deficiency and 2,8-dihydroxyadenine (DHA) nephrolithiasis. The disease phenotype is more severe in male mice and is age-dependent. To identify...

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PMID: 12486089
DOI: 10.1177/002215540205001211

Genes

APRT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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