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Progress in the Development of Selective Inhibitors of Aurora Kinases

1 Aug 2005

Abstract excerpt

Errors in the mitotic process are thought to be one of the principal sources of the genetic instability that hallmarks cancer. Unsurprisingly, many of the proteins that regulate mitosis are aberrantly expressed in tumour cells when compared to their normal counterparts. These may represent a good source of targets for the development of novel anti-cancer agents. The Aurora kinases represent one such family of...

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PMID: 16101420
DOI: 10.2174/1568026054637719

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