Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Design strategies, SAR, and mechanistic insight of Aurora kinase inhibitors in cancer

2 May 2021

Abstract excerpt

Aurora kinases (AURKs) are serine/threonine protein kinases that play a critical role during cell proliferation. Three isoforms of AURKs reported in mammals include AURKA, AURKB, AURKC, and all share a similar C-terminal catalytic domain with differences in their subcellular location, substrate specificity, and function. Recent research reports indicate an elevated expression of these kinases in several cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Microtubule and mitosis dynamics
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33934503
DOI: 10.1111/cbdd.13850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Design strategies, SAR, and mechanistic insight of Aurora kinase inhibitors in cancerPMID 33934503Read ↗

Aurora kinase inhibitors: Progress towards the clinicSemantic proximity Read ↗

Aurora kinase inhibitors as anti-cancer therapySemantic proximity Read ↗

Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for CancerSemantic proximity Read ↗

Clinical Experience with Aurora Kinase Inhibitors: A ReviewSemantic proximity Read ↗

Aurora Kinases as Anticancer Drug TargetsSemantic proximity Read ↗

A comprehensive review on role of Aurora kinase inhibitors (AKIs) in cancer therapeuticsSemantic proximity Read ↗

Aurora kinase inhibitor patents and agents in clinical testing: an update (2009 – 10)Semantic proximity Read ↗

Aurora B Inhibitors as Cancer TherapeuticsSemantic proximity Read ↗

Biology of Aurora A kinase: Implications in cancer manifestation and therapySemantic proximity Read ↗

Aurora Kinase Inhibitors - Rising Stars in Cancer Therapeutics?Semantic proximity Read ↗

Aurora Kinases: New Targets for Cancer TherapySemantic proximity Read ↗

Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.