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Aurora Kinases: New Targets for Cancer Therapy

1 Dec 2006

Abstract excerpt

The Aurora kinase family is a collection of highly related serine/threonine kinases that functions as a key regulator of mitosis. In mammalian cells, Aurora has evolved into three related kinases known as Aurora-A, Aurora-B, and Aurora-C. These kinases are overexpressed in a number of human cancers, and transfection studies have established Aurora-A as a bone fide oncogene. Because Aurora overexpression is...

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PMID: 17145803
DOI: 10.1158/1078-0432.ccr-06-1405

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