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Article

Effects of hypothalamic neurodegeneration on energy balance.

PLoS biology - 1 Dec 2005

Xu Allison Wanting, Kaelin Christopher B, Morton Gregory J, Ogimoto Kayoko, Stanhope Kimber, Graham James, Baskin Denis G, Havel Peter, Schwartz Michael W, Barsh Gregory S

Abstract excerpt

Normal aging in humans and rodents is accompanied by a progressive increase in adiposity. To investigate the role of hypothalamic neuronal circuits in this process, we used a Cre-lox strategy to create mice with specific and progressive degeneration of hypothalamic neurons that express agouti-related protein (Agrp) or proopiomelanocortin (Pomc), neuropeptides that promote positive or negative energy balance,...

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Source

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Identifiers

PMID: 16296893
DOI: 10.1371/journal.pbio.0030415
PMCID: PMC1287504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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