Article
Activation of Stat3 signaling in AgRP neurons promotes locomotor activity.
Cell metabolism - 1 Mar 2008
Mesaros Andrea, Koralov Sergei B, Rother Eva, Wunderlich F Thomas, Ernst Marianne B, Barsh Gregory S, Rajewsky Klaus, Brüning Jens C
Abstract excerpt
Leptin, an adipocyte-derived hormone, acts on hypothalamic neurons located in the arcuate nucleus (ARC) of the hypothalamus to regulate energy homeostasis. One of the leptin-regulated neuronal subtypes in the ARC are agouti-related peptide (AgRP)-expressing neurons, which are involved in the regulation of food intake and are directly inhibited by leptin. Leptin activates the signal transducer and activator of...
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