Article
Identification of hepatitis B virus X gene mutation in Hong Kong patients with hepatocellular carcinoma.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Sept 2005
Chen G G, Li M Y, Ho R L K, Chak E C W, Lau W Y, Lai P B S
Abstract excerpt
BACKGROUND: Chronic infection by hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC) in man. The viral transactivator HBV X (HBx) gene plays a critical role in the molecular pathogenesis of HBV-related HCC. OBJECTIVES: The aim of this study was to investigate whether there were particular HBx mutations associated with the Chinese Hong Kong patients with HCC. STUDY DESIGN: We have...
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