Article
Comparison of hepatitis B X gene mutation between patients with hepatocellular carcinoma and patients with chronic hepatitis B.
Virus genes - 1 Apr 2011
Fan Wenmei, Shi Bingyi, Wei Hongshan, Du Guosheng, Song Shujing
Abstract excerpt
Hepatitis B virus (HBV), a major causative agent of hepatocellular carcinoma (HCC), encodes an oncogenic X protein (HBx) that transcriptionally activates multiple viral and cellular promoters. The present study aimed to identify the specific gene mutation related to the clinical outcome of HCC. S...
Topics
- Adult
- Base Sequence
- Carcinoma, Hepatocellular
- DNA Mutational Analysis
- DNA, Viral
- Enhancer Elements, Genetic
- Female
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans
- Liver Neoplasms
- Male
- Molecular Sequence Data
- Mutation
- TATA Box
- Trans-Activators
- Viral Regulatory and Accessory Proteins