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Article

Hepatitis B virus X gene and hepatocarcinogenesis.

Journal of gastroenterology - 1 Aug 2011

Ng Sue-Ann, Lee Caroline

Abstract excerpt

Chronic hepatitis B virus (HBV) infection has been identified as a major risk factor in hepatocellular carcinoma (HCC), which is one of the most common cancers worldwide. The pathogenesis of HBV-mediated hepatocarcinogenesis is, however, incompletely understood. Evidence suggests that the HBV X protein (HBx) plays a crucial role in HCC development. HBx is a multifunctional regulator that modulates transcription,...

Topics

Apoptosis
Carcinoma, Hepatocellular
DNA Repair
Epigenesis, Genetic
Hepatitis B virus
Hepatitis B, Chronic
Humans
Liver Neoplasms
Mutation
Trans-Activators
Viral Regulatory and Accessory Proteins

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Identifiers

PMID: 21647825
DOI: 10.1007/s00535-011-0415-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21647825-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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