Article
Hepatitis B virus X gene and hepatocarcinogenesis.
Journal of gastroenterology - 1 Aug 2011
Ng Sue-Ann, Lee Caroline
Abstract excerpt
Chronic hepatitis B virus (HBV) infection has been identified as a major risk factor in hepatocellular carcinoma (HCC), which is one of the most common cancers worldwide. The pathogenesis of HBV-mediated hepatocarcinogenesis is, however, incompletely understood. Evidence suggests that the HBV X protein (HBx) plays a crucial role in HCC development. HBx is a multifunctional regulator that modulates transcription,...
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