Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Involvement of p21ras in activation of extracellular signal-regulated kinase 2.

Nature - 18 Jun 1992

de Vries-Smits A M, Burgering B M, Leevers S J, Marshall C J, Bos J L

Abstract excerpt

Many growth factors upon stimulation of their receptors induce the activity of extracellular signal-regulated kinases, ERKs, also known as MAP kinases. Several of these growth factors also activate the ras proto-oncogene product, p21ras (Ras), by stimulating the conversion of the inactive GDP-bound form of Ras to the active GTP-bound form. We have shown that direct introduction of p21ras oncoprotein into cells in...

Topics

Cell Line
DNA, Recombinant
Enzyme Activation
Genes, ras
Humans
Insulin
Mitogen-Activated Protein Kinase 1
Mutation
Oncogene Protein p21(ras)
Platelet-Derived Growth Factor
Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Mas

Signal Transduction

Tetradecanoylphorbol Acetate

Transfection

Vaccinia virus

Source

Identifiers

PMID: 1608472
DOI: 10.1038/357602a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1608472-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of p21ras in activation of extracellular signal-regulated kinase 2.PMID 1608472Read ↗

Insulin stimulation of gene expression mediated by p21ras activation.Semantic proximity Read ↗

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.Semantic proximity Read ↗

Platelet-derived growth factor-induced p21ras-mediated signaling is independent of platelet-derived growth factor receptor interaction with GTPase-activating protein or phosphatidylinositol-3-kinase.Semantic proximity Read ↗

Activation of p70/p85 S6 kinase by a pathway independent of p21ras.Semantic proximity Read ↗

Phosphatidylinositol-3-OH kinase as a direct target of Ras.Semantic proximity Read ↗

A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.Semantic proximity Read ↗

Involvement of p21ras in Xenopus mesoderm induction.Semantic proximity Read ↗

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase.Semantic proximity Read ↗

The dominant negative Ras mutant, N17Ras, can inhibit signaling independently of blocking Ras activation.Semantic proximity Read ↗

Ras-dependent activation of the small GTPase Ral.Semantic proximity Read ↗

Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1.Semantic proximity Read ↗

Activation of big mitogen-activated protein kinase-1 regulates smooth muscle cell replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.