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Article

Involvement of p21ras in activation of extracellular signal-regulated kinase 2.

Nature - 18 Jun 1992

de Vries-Smits A M, Burgering B M, Leevers S J, Marshall C J, Bos J L

Abstract excerpt

Many growth factors upon stimulation of their receptors induce the activity of extracellular signal-regulated kinases, ERKs, also known as MAP kinases. Several of these growth factors also activate the ras proto-oncogene product, p21ras (Ras), by stimulating the conversion of the inactive GDP-bound form of Ras to the active GTP-bound form. We have shown that direct introduction of p21ras oncoprotein into cells in...

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PMID: 1608472
DOI: 10.1038/357602a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Involvement of p21ras in activation of extracellular signal-regulated kinase 2.PMID 1608472Read ↗

Insulin stimulation of gene expression mediated by p21ras activation.Semantic proximity Read ↗

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.Semantic proximity Read ↗

Platelet-derived growth factor-induced p21ras-mediated signaling is independent of platelet-derived growth factor receptor interaction with GTPase-activating protein or phosphatidylinositol-3-kinase.Semantic proximity Read ↗

Activation of p70/p85 S6 kinase by a pathway independent of p21ras.Semantic proximity Read ↗

Phosphatidylinositol-3-OH kinase as a direct target of Ras.Semantic proximity Read ↗

A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.Semantic proximity Read ↗

Involvement of p21ras in Xenopus mesoderm induction.Semantic proximity Read ↗

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The dominant negative Ras mutant, N17Ras, can inhibit signaling independently of blocking Ras activation.Semantic proximity Read ↗

Ras-dependent activation of the small GTPase Ral.Semantic proximity Read ↗

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Activation of big mitogen-activated protein kinase-1 regulates smooth muscle cell replication.Semantic proximity Read ↗

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