Article
Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase.
Science (New York, N.Y.) - 11 Jun 1993
Moodie S A, Willumsen B M, Weber M J, Wolfman A
Abstract excerpt
The guanosine triphosphate (GTP)-binding protein Ras functions in regulating growth and differentiation; however, little is known about the protein interactions that bring about its biological activity. Wild-type Ras or mutant forms of Ras were covalently attached to an insoluble matrix and then...
Topics
- Animals
- Brain
- Guanosine Triphosphate
- Guanylyl Imidodiphosphate
- In Vitro Techniques
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase Kinases
- Mutation
- Phosphorylation
- Protein Binding
- Protein Kinases
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-raf
- Proto-Oncogene Proteins p21(ras)
- Rats
- Signal Transduction