Article
Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase.
Science (New York, N.Y.) - 11 Jun 1993
Moodie S A, Willumsen B M, Weber M J, Wolfman A
Abstract excerpt
The guanosine triphosphate (GTP)-binding protein Ras functions in regulating growth and differentiation; however, little is known about the protein interactions that bring about its biological activity. Wild-type Ras or mutant forms of Ras were covalently attached to an insoluble matrix and then used to examine the interaction of signaling proteins with Ras. Forms of Ras activated either by mutation (Gly12Val) or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.