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Article

The dominant negative Ras mutant, N17Ras, can inhibit signaling independently of blocking Ras activation.

The Journal of biological chemistry - 24 Mar 2000

Stewart S, Guan K L

Abstract excerpt

Ras plays an important role in a variety of cellular functions, including growth, differentiation, and oncogenic transformation. For instance, Ras participates in the activation of Raf, which phosphorylates and activates mitogen-activated protein kinase kinase (MEK), which then phosphorylates and activates extracellular signal-regulated kinase (ERK), a mitogen-activated protein (MAP) kinase. Activation of MAP...

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PMID: 10722731
DOI: 10.1074/jbc.275.12.8854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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