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Article

Phosphatidylinositol-3-OH kinase as a direct target of Ras.

Nature - 18 Aug 1994

Rodriguez-Viciana P, Warne P H, Dhand R, Vanhaesebroeck B, Gout I, Fry M J, Waterfield M D, Downward J

Abstract excerpt

Ras (p21ras) interacts directly with the catalytic subunit of phosphatidylinositol-3-OH kinase in a GTP-dependent manner through the Ras effector site. In vivo, dominant negative Ras mutant N17 inhibits growth factor induced production of 3' phosphorylated phosphoinositides in PC12 cells, and tra...

Topics

Animals
Cell Line
Enzyme Activation
Epidermal Growth Factor
Genes, ras
Guanosine Triphosphate
Mutation
Nerve Growth Factors
PC12 Cells
Phosphatidylinositol 3-Kinases
Phosphatidylinositol Phosphates
Phosphotransferases (Alcohol Group Acceptor)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Proto-Oncogene Proteins p21(ras)

Rats

Source

Identifiers

PMID: 8052307
DOI: 10.1038/370527a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8052307-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Phosphatidylinositol-3-OH kinase as a direct target of Ras.PMID 8052307Read ↗

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