Article
Platelet-derived growth factor-induced p21ras-mediated signaling is independent of platelet-derived growth factor receptor interaction with GTPase-activating protein or phosphatidylinositol-3-kinase.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Mar 1994
Burgering B M, Freed E, van der Voorn L, McCormick F, Bos J L
Abstract excerpt
Stimulation with platelet-derived growth factor (PDGF) results in the association of several SH2 domain-containing proteins with the activated PDGF receptor, including GAP, a GTPase-activating protein of p21ras, and phosphatidylinositol-3-kinase (PI-3K). To investigate the role of GAP-PI-3K recep...
Topics
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- GTPase-Activating Proteins
- Guanine Nucleotides
- Mice
- Mitogen-Activated Protein Kinase 1
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphotransferases (Alcohol Group Acceptor)
- Platelet-Derived Growth Factor
- Proteins