Article
Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1.
Science (New York, N.Y.) - 14 Oct 1994
Sun H, Tonks N K, Bar-Sagi D
Abstract excerpt
Mitogen-activated protein kinases (MAP kinases) are common components of signaling pathways induced by diverse growth stimuli. Although the guanidine nucleotide-binding Ras proteins are known to be upstream activators of MAP kinases, the extent to which MAP kinases directly contribute to the mito...
Topics
- Animals
- Base Sequence
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Cycle Proteins
- Cell Line
- DNA
- Dual Specificity Phosphatase 1
- Enzyme Activation
- HeLa Cells
- Humans
- Immediate-Early Proteins
- JNK Mitogen-Activated Protein Kinases
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinases
- Molecular Sequence Data
- Mutation
- Phosphoprotein Phosphatases
- Protein Phosphatase 1