Article
Inhibition of Ras-induced DNA synthesis by expression of the phosphatase MKP-1.
Science (New York, N.Y.) - 14 Oct 1994
Sun H, Tonks N K, Bar-Sagi D
Abstract excerpt
Mitogen-activated protein kinases (MAP kinases) are common components of signaling pathways induced by diverse growth stimuli. Although the guanidine nucleotide-binding Ras proteins are known to be upstream activators of MAP kinases, the extent to which MAP kinases directly contribute to the mitogenic effect of Ras is as yet undefined. In this study, inhibition of MAP kinases by the MAP kinase phosphatase MKP-1...
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