Article
A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.
The Journal of biological chemistry - 30 Dec 1994
Ouwens D M, van der Zon G C, Pronk G J, Bos J L, Möller W, Cheatham B, Kahn C R, Maassen J A
Abstract excerpt
The activation of p21ras by receptor tyrosine kinases involves the translocation of the growth factor receptor bound protein 2-mammalian son of sevenless protein (Grb2-SOS) complex to the plasma membrane where p21ras is localized. Insulin receptors induce p21ras-GTP formation by two possible mech...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- CHO Cells
- Cricetinae
- GRB2 Adaptor Protein
- Guanosine Triphosphate
- Insulin Receptor Substrate Proteins
- Mitogen-Activated Protein Kinase 1
- Mutation
- Oncogene Protein p21(ras)
- Phosphoproteins
- Phosphorylation