Article
Ras-dependent activation of the small GTPase Ral.
Current biology : CB - 9 Apr 1998
Wolthuis R M, Zwartkruis F, Moen T C, Bos J L
Abstract excerpt
The small GTPase Ral is a Ras-like GTPase [1] that has been implicated in growth-factor-induced and Ras-induced DNA synthesis [2-4], and Ras-induced oncogenic transformation [3,5]. Recently, we and others found that three different Ral guanine nucleotide exchange factors (Ral GEFs) - Ral GDS, Rgl and Rlf - bind specifically to the GTP-bound form of several Ras-like GTPases [6-9]. Although oncogenic Ras is able to...
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