Ras-dependent activation of the small GTPase Ral.

doi:10.1016/s0960-9822(98)70183-6

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Article

Ras-dependent activation of the small GTPase Ral.

Current biology : CB - 9 Apr 1998

Wolthuis R M, Zwartkruis F, Moen T C, Bos J L

Abstract excerpt

The small GTPase Ral is a Ras-like GTPase [1] that has been implicated in growth-factor-induced and Ras-induced DNA synthesis [2-4], and Ras-induced oncogenic transformation [3,5]. Recently, we and others found that three different Ral guanine nucleotide exchange factors (Ral GEFs) - Ral GDS, Rgl...

Topics

3T3 Cells
Animals
Cell Line
Enzyme Activation
Epidermal Growth Factor
Fibroblasts
GTP Phosphohydrolases
GTP-Binding Proteins
Genes, ras
Insulin
Lysophospholipids
Mice
Mutation
Rats
Receptors, Endothelin
Receptors, Platelet-Derived Growth Factor
Recombinant Fusion Proteins
ral GTP-Binding Proteins

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