Article
Activation of p70/p85 S6 kinase by a pathway independent of p21ras.
Nature - 29 Sept 1994
Ming X F, Burgering B M, Wennström S, Claesson-Welsh L, Heldin C H, Bos J L, Kozma S C, Thomas G
Abstract excerpt
The enzymes p70s6k and p85s6k are two isoforms of the same kinase and are important in mitogenesis. Both isoforms are activated by a complex phosphorylation event and lie on a common signalling pathway, distinct from that of the p42mapk/p44mapk kinases. Activation of p42mapk/p44mapk is triggered...
Topics
- 3T3 Cells
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- Enzyme Activation
- Humans
- Mice
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinases
- Mutation
- Phosphatidylinositol 3-Kinases
- Phosphorylation
- Phosphotransferases (Alcohol Group Acceptor)
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins c-raf
- Proto-Oncogene Proteins p21(ras)
- Receptors, Platelet-Derived Growth Factor