Article
Activation of p70/p85 S6 kinase by a pathway independent of p21ras.
Nature - 29 Sept 1994
Ming X F, Burgering B M, Wennström S, Claesson-Welsh L, Heldin C H, Bos J L, Kozma S C, Thomas G
Abstract excerpt
The enzymes p70s6k and p85s6k are two isoforms of the same kinase and are important in mitogenesis. Both isoforms are activated by a complex phosphorylation event and lie on a common signalling pathway, distinct from that of the p42mapk/p44mapk kinases. Activation of p42mapk/p44mapk is triggered by sequential activation of the GDP-GTP exchange factor Sos, the GTP-binding protein p21ras, and protein kinases p74raf...
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