Article
Insulin stimulation of gene expression mediated by p21ras activation.
The EMBO journal - 1 May 1991
Burgering B M, Medema R H, Maassen J A, van de Wetering M L, van der Eb A J, McCormick F, Bos J L
Abstract excerpt
In fibroblasts, insulin is a weak mitogen and does not induce expression of c-fos, c-jun or p33. However, increasing the expression levels of either normal p21Hras or the insulin receptor, but not mutant p21Hras, enables insulin to induce the expression of these genes. In cells expressing elevated levels of insulin receptor, this process involves a rapid increase in p21rasGTP levels (from 20% to 70% GTP as a...
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