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Article

Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression.

Molecular and cellular biology - 1 Dec 1991

Medema R H, Wubbolts R, Bos J L

Abstract excerpt

Insulin induces a rapid activation of p21ras in NIH 3T3 and Chinese hamster ovary cells that overexpress the insulin receptor. Previously, we suggested that p21ras may mediate insulin-induced gene expression. To test such a function of p21ras more directly, we studied the effect of different dominant inhibitory mutants of p21ras on the induction of gene expression in response to insulin. We transfected a...

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Identifiers

PMID: 1658621
DOI: 10.1128/mcb.11.12.5963-5967.1991
PMCID: PMC361755

Genes

CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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