Article
Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli.
Developmental biology - 15 Nov 2005
May Scott R, Ashique Amir M, Karlen Mattias, Wang Baolin, Shen Yiguo, Zarbalis Kostantinos, Reiter Jeremy, Ericson Johan, Peterson Andrew S
Abstract excerpt
Sonic Hedgehog (Shh) signals are transduced into nuclear ratios of Gli transcriptional activator versus repressor. The initial part of this process is accomplished by Shh acting through Patched (Ptc) to regulate Smoothened (Smo) activity. The mechanisms by which Ptc regulates Smo, and Smo activity is transduced to processing of Gli proteins remain unclear. Recently, a forward genetic approach in mice identified a...
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