Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain.

doi:10.1016/j.ydbio.2008.09.019

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Article

Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain.

Developmental biology - 1 Jan 2009

Gorivodsky Marat, Mukhopadhyay Mahua, Wilsch-Braeuninger Michaela, Phillips Matthew, Teufel Andreas, Kim Changmee, Malik Nasir, Huttner Wieland, Westphal Heiner

Abstract excerpt

IFT172, also known as Selective Lim-domain Binding protein (SLB), is a component of the intraflagellar transport (IFT) complex. In order to evaluate the biological role of the Ift172 gene, we generated a loss-of-function mutation in the mouse. The resulting Slb mutant embryos die between E12.5 an...

Topics

Adaptor Proteins, Signal Transducing
Animals
Biomarkers
Body Patterning
Brain
Cell Death
Cilia
Cytoskeletal Proteins
Embryo, Mammalian
Endoderm
Gene Deletion
Gene Expression Regulation, Developmental
Gene Targeting
Hedgehog Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Holoprosencephaly

Intracellular Signaling Peptides and Proteins

Mammals

Mice

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Identifiers

PMID: 18930042
DOI: 10.1016/j.ydbio.2008.09.019
PMCID: PMC2613858

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-18930042-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.