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Article

Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain.

Developmental biology - 1 Jan 2009

Gorivodsky Marat, Mukhopadhyay Mahua, Wilsch-Braeuninger Michaela, Phillips Matthew, Teufel Andreas, Kim Changmee, Malik Nasir, Huttner Wieland, Westphal Heiner

Abstract excerpt

IFT172, also known as Selective Lim-domain Binding protein (SLB), is a component of the intraflagellar transport (IFT) complex. In order to evaluate the biological role of the Ift172 gene, we generated a loss-of-function mutation in the mouse. The resulting Slb mutant embryos die between E12.5 and 13.0, and exhibit severe cranio-facial malformations, failure to close the cranial neural tube, holoprosencephaly,...

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Identifiers

PMID: 18930042
DOI: 10.1016/j.ydbio.2008.09.019
PMCID: PMC2613858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Intraflagellar transport protein 172 is essential for primary cilia formation and plays a vital role in patterning the mammalian brain.PMID 18930042Read ↗

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Intraflagellar transport protein IFT172 contains a C-terminal ubiquitin-binding U-box-like domain involved in ciliary signalingSemantic proximity Read ↗

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