Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.

doi:10.1016/j.ydbio.2008.10.020

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Article

Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4.

Developmental biology - 1 Jan 2009

Cortellino Salvatore, Wang Chengbing, Wang Baolin, Bassi Maria Rosaria, Caretti Elena, Champeval Delphine, Calmont Amelie, Jarnik Michal, Burch John, Zaret Kenneth S, Larue Lionel, Bellacosa Alfonso

Abstract excerpt

Primary cilia are assembled and maintained by evolutionarily conserved intraflagellar transport (IFT) proteins that are involved in the coordinated movement of macromolecular cargo from the basal body to the cilium tip and back. The IFT machinery is organized in two structural complexes named com...

Topics

Adaptor Proteins, Signal Transducing
Alleles
Animals
Body Patterning
Cilia
Cytoskeletal Proteins
DNA Repair
Embryo Loss
Embryo, Mammalian
Embryonic Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Endodeoxyribonucleases

Extremities

Gene Deletion

Gene Expression Regulation, Developmental

Gene Silencing

Hedgehog Proteins

Homozygote

Intracellular Signaling Peptides and Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19000668
DOI: 10.1016/j.ydbio.2008.10.020
PMCID: PMC2645042

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-19000668-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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