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Article

Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting.

The Journal of clinical investigation - 1 Jun 1999

Kersten S, Seydoux J, Peters J M, Gonzalez F J, Desvergne B, Wahli W

Abstract excerpt

Prolonged deprivation of food induces dramatic changes in mammalian metabolism, including the release of large amounts of fatty acids from the adipose tissue, followed by their oxidation in the liver. The nuclear receptor known as peroxisome proliferator-activated receptor alpha (PPARalpha) was f...

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Identifiers

PMID: 10359558
DOI: 10.1172/JCI6223
PMCID: PMC408372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10359558-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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