Article
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones.
The Journal of clinical investigation - 1 Aug 2003
Norris Andrew W, Chen Lihong, Fisher Simon J, Szanto Ildiko, Ristow Michael, Jozsi Alison C, Hirshman Michael F, Rosen Evan D, Goodyear Laurie J, Gonzalez Frank J, Spiegelman Bruce M, Kahn C Ronald
Abstract excerpt
Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) by thiazolidinediones (TZDs) improves insulin resistance by increasing insulin-stimulated glucose disposal in skeletal muscle. It remains debatable whether the effect of TZDs on muscle is direct or indirect via adipose tissue. We therefore generated mice with muscle-specific PPARgamma knockout (MuPPARgammaKO) using Cre/loxP recombination....
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