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Article

Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity.

Developmental cell - 1 Oct 2003

Rangwala Shamina M, Rhoades Ben, Shapiro Jennifer S, Rich A Sophie, Kim Jason K, Shulman Gerald I, Kaestner Klaus H, Lazar Mitchell A

Abstract excerpt

Obesity-associated diabetes is epidemic in industrialized societies. The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) is highly expressed in adipose tissue and the presumed molecular target for antidiabetic thiazolidinedione drugs that reverse insulin resistance but also promote weight gain. Phosphorylation reduces the activity of PPARgamma in vitro, but physiological relevance...

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Source

Identifiers

PMID: 14536066
DOI: 10.1016/s1534-5807(03)00274-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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