Article
PPARdelta regulates glucose metabolism and insulin sensitivity.
Proceedings of the National Academy of Sciences of the United States of America - 28 Feb 2006
Lee Chih-Hao, Olson Peter, Hevener Andrea, Mehl Isaac, Chong Ling-Wa, Olefsky Jerrold M, Gonzalez Frank J, Ham Jungyeob, Kang Heonjoong, Peters Jeffrey M, Evans Ronald M
Abstract excerpt
The metabolic syndrome is a collection of obesity-related disorders. The peroxisome proliferator-activated receptors (PPARs) regulate transcription in response to fatty acids and, as such, are potential therapeutic targets for these diseases. We show that PPARdelta (NR1C2) knockout mice are metabolically less active and glucose-intolerant, whereas receptor activation in db/db mice improves insulin sensitivity....
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