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Article

Genes and pathophysiology of type 2 diabetes: more than just the Randle cycle all over again.

The Journal of clinical investigation - 1 Nov 2004

Shuldiner Alan R, McLenithan John C

Abstract excerpt

The Randle cycle, which has been invoked to explain the reciprocal relationship between fatty acid oxidation and glucose oxidation, has long been implicated as a potential mechanism for hyperglycemia and type 2 diabetes mellitus (T2DM). Now genetic, functional genomic, and transgenic approaches h...

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Identifiers

PMID: 15545992
DOI: 10.1172/JCI23586
PMCID: PMC525752

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15545992-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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