Article
Selective activation of PPARgamma in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance.
American journal of physiology. Endocrinology and metabolism - 1 Jan 2010
Amin Rajesh H, Mathews Suresh T, Camp Heidi S, Ding Liyun, Leff Todd
Abstract excerpt
The nuclear receptor peroxisome proliferator-activated receptor (PPAR)gamma plays a key role in regulating whole body glucose homeostasis and insulin sensitivity. Although it is expressed most highly in adipose, it is also present at lower levels in many tissues, including skeletal muscle. The role muscle PPARgamma plays in metabolic regulation and in mediating the antidiabetic effects of the thiazolidinediones...
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