Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16.

doi:10.1016/j.cub.2005.06.042

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Article

Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16.

Current biology : CB - 26 Jul 2005

Soranzo Nicole, Bufe Bernd, Sabeti Pardis C, Wilson James F, Weale Michael E, Marguerie Richard, Meyerhof Wolfgang, Goldstein David B

Abstract excerpt

BACKGROUND: During periods of human expansion into new environments, recognition of bitter natural toxins through taste may have conferred an important selective advantage. The G protein-coupled receptor encoded by TAS2R16 mediates response to salicin, amygdalin, and many bitter beta-glucopyranosides. beta-glucopyranosides are ubiquitous in nature, with many having a highly toxic cyanogenic activity. RESULTS: We...

Topics

Alleles
Amygdalin
Arbutin
Base Sequence
Benzyl Alcohols
Evolution, Molecular
Genetic Variation
Genetics, Population
Glucosides
Glycosides
Haplotypes
Humans
Immunohistochemistry
Molecular Sequence Data

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, G-Protein-Coupled

Selection, Genetic

Sequence Analysis, DNA

Taste Receptors, Type 2

Source

Open in PubMed

Identifiers

PMID: 16051168
DOI: 10.1016/j.cub.2005.06.042

Provenance

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