Article
Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal.
Scientific reports - 3 May 2016
Risso Davide S, Mezzavilla Massimo, Pagani Luca, Robino Antonietta, Morini Gabriella, Tofanelli Sergio, Carrai Maura, Campa Daniele, Barale Roberto, Caradonna Fabio, Gasparini Paolo, Luiselli Donata, Wooding Stephen, Drayna Dennis
Abstract excerpt
The ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter taste receptor gene. It has long been hypothesized that global genetic diversity at this locus evolved under pervasive pressures from balancing natural selection. H...
Topics
- Databases, Genetic
- Evolution, Molecular
- Genetic Variation
- Haplotypes
- Humans
- Linkage Disequilibrium
- Phenylthiourea
- Propylthiouracil
- Receptors, G-Protein-Coupled
- Selection, Genetic
- Taste
- Taste Receptors, Type 2