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Article

Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal.

Scientific reports - 3 May 2016

Risso Davide S, Mezzavilla Massimo, Pagani Luca, Robino Antonietta, Morini Gabriella, Tofanelli Sergio, Carrai Maura, Campa Daniele, Barale Roberto, Caradonna Fabio, Gasparini Paolo, Luiselli Donata, Wooding Stephen, Drayna Dennis

Abstract excerpt

The ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter taste receptor gene. It has long been hypothesized that global genetic diversity at this locus evolved under pervasive pressures from balancing natural selection. However, recent high-resolution population genetic studies of TAS2Rs suggest that demographic events have played a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Taste Receptors, Type 2

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Identifiers

PMID: 27138342
DOI: 10.1038/srep25506
PMCID: PMC4853779

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Source receipt: pubmed, retrieved 7 Sept 2026.

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