Article
Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin.
Alcoholism, clinical and experimental research - 1 Feb 2007
Wang Jen C, Hinrichs Anthony L, Bertelsen Sarah, Stock Heather, Budde John P, Dick Danielle M, Bucholz Kathleen K, Rice John, Saccone Nancy, Edenberg Howard J, Hesselbrock Victor, Kuperman Samuel, Schuckit Marc A, Bierut Laura J, Goate Alison M
Abstract excerpt
BACKGROUND: A novel family of G protein-coupled receptors, TAS2Rs, has recently been characterized and linked to sensitivity to bitter taste compounds. We have previously reported that a missense mutation in the TAS2R16 gene reduces the sensitivity of the receptor to bitter-taste stimuli and that it is associated with risk for alcohol dependence. Other family-based studies on the genetic transmittance of taste...
Topics
- Black or African American
- Alcohol Drinking
- Alcoholism
- Female
- Genetic Variation
- Haplotypes
- Humans
- Male
- Mutation, Missense
- Phenotype