Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations.

Human molecular genetics - 1 Jul 2006

Akey Joshua M, Swanson Willie J, Madeoy Jennifer, Eberle Michael, Shriver Mark D

Abstract excerpt

A striking footprint of positive selection was recently identified on chromosome 7q34-35 that spans at least 115 kb and encompasses four known genes (KEL, TRPV5, TRPV6, EPHB6). The signature of selection was observed in only one of the two populations analyzed suggesting the action of geographically restricted selective pressures. However, as only two populations were analyzed, it remains unknown whether the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Channels
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Evolution, Molecular

Share to Genetics, Population

Share to Geography

Share to Haplotypes

Share to Linkage Disequilibrium

Share to TRPV Cation Channels

Source

Identifiers

PMID: 16717058
DOI: 10.1093/hmg/ddl134

Genes

TRPV6
EPHB6
KEL
TRPV5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations.PMID 16717058Read ↗

Parallel selection on TRPV6 in human populations.Semantic proximity Read ↗

Structure-function analyses of human TRPV6 ancestral and derived haplotypes.Semantic proximity Read ↗

Derived (mutated)-types of TRPV6 channels elicit greater Ca²+ influx into the cells than ancestral-types of TRPV6: evidence from Xenopus oocytes and mammalian cell expression system.Semantic proximity Read ↗

TRPV6 as a Putative Genomic Susceptibility Locus Influencing Racial Disparities in Cancer.Semantic proximity Read ↗

Genetic variation and recent positive selection in worldwide human populations: evidence from nearly 1 million SNPs.Semantic proximity Read ↗

Signals of recent positive selection in a worldwide sample of human populations.Semantic proximity Read ↗

Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infectionSemantic proximity Read ↗

TRPV6 Variants Interfere with Maternal-Fetal Calcium Transport through the Placenta and Cause Transient Neonatal Hyperparathyroidism.Semantic proximity Read ↗

Distinguishing between selective sweeps from standing variation and from a de novo mutation.Semantic proximity Read ↗

Selection on the human bitter taste gene, TAS2R16, in Eurasian populations.Semantic proximity Read ↗

Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa.Semantic proximity Read ↗

Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.