Article
Limited evidence for adaptive evolution and functional effect of allelic variation at rs702424 in the promoter of the TAS2R16 bitter taste receptor gene in Africa.
Journal of human genetics - 1 Jun 2014
Campbell Michael C, Ranciaro Alessia, Zinshteyn Daniel, Rawlings-Goss Renata, Hirbo Jibril, Thompson Simon, Woldemeskel Dawit, Froment Alain, Omar Sabah A, Bodo Jean-Marie, Nyambo Thomas, Belay Gurja, Drayna Dennis, Breslin Paul A S, Tishkoff Sarah A
Abstract excerpt
Bitter taste perception, mediated by receptors encoded by the TAS2R loci, has important roles in human health and nutrition. Prior studies have demonstrated that nonsynonymous variation at site 516 in the coding exon of TAS2R16, a bitter taste receptor gene on chromosome 7, has been subject to positive selection and is strongly correlated with differences in sensitivity to salicin, a bitter anti-inflammatory...
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