Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence.

doi:10.1086/499253

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Article

Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence.

American journal of human genetics - 1 Jan 2006

Hinrichs Anthony L, Wang Jen C, Bufe Bernd, Kwon Jennifer M, Budde John, Allen Rebecca, Bertelsen Sarah, Evans Whitney, Dick Danielle, Rice John, Foroud Tatiana, Nurnberger John, Tischfield Jay A, Kuperman Samuel, Crowe Raymond, Hesselbrock Victor, Schuckit Marc, Almasy Laura, Porjesz Bernice, Edenberg Howard J, Begleiter Henri, Meyerhof Wolfgang, Bierut Laura J, Goate Alison M

Abstract excerpt

A coding single-nucleotide polymorphism (cSNP), K172N, in hTAS2R16, a gene encoding a taste receptor for bitter beta -glucopyranosides, shows significant association with alcohol dependence (P = .00018). This gene is located on chromosome 7q in a region reported elsewhere to exhibit linkage with alcohol dependence. The SNP is located in the putative ligand-binding domain and is associated with an increased...

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PMID: 16385453
DOI: 10.1086/499253
PMCID: PMC1380207

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