Article
Interaction of Rv1625c, a mycobacterial class IIIa adenylyl cyclase, with a mammalian congener.
Molecular microbiology - 1 Aug 2005
Guo Ying Lan, Kurz Ursula, Schultz Anita, Linder Jürgen U, Dittrich Dorothea, Keller Christine, Ehlers Stefan, Sander Peter, Schultz Joachim E
Abstract excerpt
The adenylyl cyclase Rv1625c from Mycobacterium tuberculosis codes for a protein with six transmembrane spans and a catalytic domain, i.e. it corresponds to one half of the pseudoheterodimeric mammalian adenylyl cyclases (ACs). Rv1625c is active as a homodimer. We investigated the role of the Rv1625c membrane domain and demonstrate that it efficiently dimerizes the protein resulting in a 7.5-fold drop in K(m) for...
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