Article
Transmembrane receptor chimeras to probe HAMP domain function.
Methods in enzymology - 1 Jan 2010
Linder Jürgen U, Schultz Joachim E
Abstract excerpt
HAMP domains are the central signal converters in bacterial chemotaxis receptors and chemosensory histidine kinases. They link the signal input modules in these proteins, that is, the ligand-binding domains, to the output modules, for example, the histidine kinase domain. A similar architecture is present in the adenylyl cyclase (AC) Rv3645 from Mycobacterium tuberculosis, where a HAMP domain is positioned...
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