Article
The Rv0805 Gene from <i>Mycobacterium tuberculosis</i> Encodes a 3‘,5‘-Cyclic Nucleotide Phosphodiesterase: Biochemical and Mutational Analysis
5 Nov 2005
Abstract excerpt
Mycobacterium tuberculosis is an important human pathogen and has developed sophisticated mechanisms to evade the host immune system. These could involve the use of cyclic nucleotide-dependent signaling systems, since the M. tuberculosis genome encodes a large number of functional adenylyl cyclases. Using bioinformatic approaches, we identify, clone, and biochemically characterize the Rv0805 gene product, the...
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